[Objective]To investigate the correlation of disease activity with levels of insulin-like growth factor-2(IGF-2)and insulin-like growth factor binding protein-6(IGFBP-6)in the peripheral blood of patients with Rheumatoid Arthritis(RA).[Methods]A total of 158 RA patients treated in our hospital were divided in-to high activity,moderate activity,and low activity groups based on the disease activity score of 28 joints.The levels of IGF-2 and IGFBP-6 in the peripheral blood of the three groups were compared.The relationship of different disease activities with the expression levels of IGF-2 and IGFBP-6 was evaluated;And the influencing factors of disease activity were analyzed as well.[Results]Among the 158 RA patients,61(38.61%)were in the high activity group,59(37.34%)in the moderate activity group,and 38(24.05%)in the low activity group.The IGF-2 level in the high activity group was higher than that in the moderate and low activity groups,while the IGFBP-6 level was lower than that in the moderate and low activity groups.The moderate activity group's IGF-2 level was higher than that of the low activity group,and the IGFBP-6 level was lower than that of the low activity group,with significant differences(P＜0.05).There was a negative correlation of the dis-ease activity with the expression level of IGF-2(P＜0.001),and a positive correlation with the expression lev-el of IGFBP-6(P＜0.001).Multifactorial analysis showed that high white blood cell count,high expression level of IGF-2,and low expression level of IGFBP-6 were risk factors for high disease activity in RA patients(P＜0.05).[Conclusion]In RA patients with high disease activity,the expression level of IGF-2 in peripheral blood is higher,which is negatively correlated with disease activity;And the expression level of IGFBP-6 in RA patients with high disease activity is lower,which is positively correlated with disease activity.
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