Efficacy Analysis of Dapagliflozin Combined with Metformin in the Treatment of Patients with Type 2 Diabetes
[Objective]To investigate the clinical efficacy of dapagliflozin combined with metformin hydrochloride in the treatment of type 2 diabetes(T2DM).[Methods]A total of 87 patients with type 2 diabetes treated in our hospital from September 2020 to September 2023 were selected and divided into the observation group(treated with dapagliflozin combined with metformin hydrochloride,n =44)and the control group(treated with metformin hydrochloride,n =43)by random number table method.Fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG)and glycosylated hemoglobin(HbA1c),blood glucose standard deviation(sDBG),mean blood glucose fluctuation range(MAGE),inflam-matory factors[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),serum homocysteine(Hcy),cystatin C(cys C)],endocrine hormones[fasting insulin(Fins),pancreatic islandβcell index(HOMA-β),insulin sensitivity index(HOMA-IR)],oxidative stress level[superoxide dismutase(SOD),catalase(CAT)]and incidence of ad-verse reactions were compared between the two groups before and after treatment.[Results]Compared to before treat-ment,the levels of FPG,2hPG,HbA1c,sDBG,MAGE,CRP,TNF-α,IL-6,Hcy and cys C in the two groups of T2DM patients decreased after treatment,while the above measurements in the observation group were significantly lower than those in the control group with statistical significance(P＜0.05).Fins,SOD,CAT levels and HOMA-βof both groups increased after treatment if compared with before treatment,and their values in the observation group were signifi-cantly higher than those in the control group.The HOMA-IR of both groups decreased after treatment,and HOMA-IR level in the observation group was significantly lower than that in the control group.The difference was statistically signif-icant(P＜0.05).The incidence of adverse reactions in the observation group was 13.64%,compared with 23.26%in the control group,the difference was not statistically significant(χ2 =1.341,P =0.247).[Conclusion]Dapagliflozin com-bined with metformin hydrochloride can effectively reduce the levels of blood glucose and inflammatory factors,improve the function of islet cells in the treatment of type 2 diabetes patients,and it is safe and worthy of clinical application.
万方数据
维普
