The Application Effect of Improved Electroconvulsive Therapy Combined with High-frequency rTMS in Patients with Schizophrenia and its Impact on Cognitive Function
[Objective]To explore the application effect of modified electroconvulsive therapy(MECT)com-bined with high-frequency repetitive transcranial magnetic stimulation(rTMS)in patients with schizophrenia(SCH)and its impact on cognitive function.[Methods]A total of 88 patients with schizophrenia admitted to our hospital from January 2021 to June 2023 were selected and randomly divided into an observation group and a con-trol group using a random number table method,with 44 cases in each group.Both groups were given conventional drugs,the control group was given MECT+high-frequency rTMS non irritating treatment,and the observation group was given MECT+high-frequency rTMS treatment.We compared the efficacy,Montreal Cognitive Assess-ment Scale(MoCA),Positive and Negative Symptom Scale(PANSS),serum neurotransmitters[Y-aminobutyric acid(GABA),dopamine(DA),norepinephrine(NE),5-hydroxytryptamine(5-HT)],GQOLI-74 scores,and incidence of adverse reactions between two groups.[Results]The clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treat-ment,the positive symptom score,negative symptom score,general psychopathological symptom score,and total score of the two groups decreased compared to before treatment.The observation group was lower than the control group,and the difference was statistically significant(P＜0.05).After treatment,the GQOLI-74 and MoCA scores of both groups were higher than before treatment,and the observation group was higher than the control group,with a statistically significant difference(P＜0.05).After treatment,the serum levels of NE,GABA,5-HT,and DA in both groups were higher than before treatment,and the observation group was higher than the control group,with statistical significance(P＜0.05).There was no statistically significant difference in the inci-dence of adverse reactions between the two groups of patients(P＞0.05).[Conclusion]High frequency rTMS has a significant therapeutic effect on schizophrenia,regulating neurotransmitter expression,improving cognitive func-tion,alleviating psychiatric symptoms,and improving quality of life.
Schizophrenia/THTranscranial Magnetic StimulationElectroconvulsive TherapyCognition
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