The Therapeutic Effect of Vitapex Paste Root Canal Filling in the Treatment of Pediatric Prima-ry Pulpitis and its Impact on IL-1β and IL-18 Levels
[Objective]To explore the therapeutic effect of Vitapex paste root canal filling on pulpitis of primary teeth in children and its impact on the levels of interleukin-1β(IL-1β)and interleukin-18(IL-18).[Methods]A total of 92 children with primary pulpitis treated at the Third Hospital of Xi'an City from March 2020 to March 2022 were selected and randomly divided into an observation group(n=46,52 affected teeth)and a control group(n=46,56 affected teeth)using a random number table method.The observation group received root canal filling with Vitapex paste,while the control group received treatment with zinc oxide clove oil paste.We compared the swelling disappear-ance time,pain relief time,degree of tooth pain,success rate of root canal treatment,and IL-1β and IL-18 levels be-tween two groups of pediatric patients.[Results]The swelling disappearance time and pain relief time in the observa-tion group were shorter than those in the control group(P＜0.05).Before treatment,there was no statistically sig-nificant difference in IL-1β and IL-18 levels between the two groups(P＞0.05);After treatment,the levels of IL-1βand IL-18 in both groups decreased(P＜0.05),and the observation group was lower than the control group(P＜0.05).2 days after surgery,the visual analog scale(VAS)scores of both groups were significantly lower than before surgery(P＜0.05),and the observation group was lower than the control group(P＜0.05);After 3 days of sur-gery,the VAS scores of both groups significantly decreased compared to preoperative and postoperative 2 days,and the observation group was lower than the control group(P＜0.05).Follow up for 1 year showed that in the control group,10 apical inflammations occurred,with a treatment success rate of 82.14％(46/56);Two apical inflamma-tions were observed in the observation group,with a treatment success rate of 96.15％(50/52).The success rate of root canal treatment in the observation group was higher than that in the control group,and the difference was statis-tically significant(x2=5.359,P=0.021).[Conclusion]Vitapex paste root canal filling has a significant therapeutic effect on children with primary pulpitis and can reduce IL-1β and IL-18 levels,alleviate postoperative tooth pain in pediatric patients and improve the success rate of root canal treatment.
万方数据
维普
