Differential Diagnostic Value of Peripheral Blood miR-200b-3p and miR-181b-5p Combined with Multi-Slice Spiral CT Perfusion Scan for Benign Prostatic Hyperplasia and Prostate Cancer
[Objective]To explore the differential value of multi-slice spiral CT(MSCT)perfusion scan combined with serum microRNA-200b-3p(miR-200b-3p)and microRNA-181b-5p(miR-181b-5p)in benign prostatic hyperplasia(BPH)and prostate cancer.[Methods]A total of 249 patients with prostate lesions admitted to our hospital from May 2021 to September 2023 were selected and divided into BPH group(n=144)and prostate cancer group(n=105)based on pathological results.Logistic regression analysis was used to investigate the relationship between serum miR-200b-3p,miR-181b-5p,and MSCT perfusion parameters with prostate cancer.A receiver operating characteristic curve was plotted to analyze the diagnostic value of MSCT perfusion parameters combined with serum miR-200b-3p and miR-181b-5p for prostate cancer.[Results]The serum miR-200b-3p levels in the prostate cancer group were higher than those in the BPH group,while the serum miR-181b-5p levels were lower than those in the BPH group(P＜0.05).The rBF and PS of pa-tients in the prostate cancer group were significantly higher than those in the BPH group(P＜0.05).The area under the curve of rBF,PS,miR-200b-3p,and miR-181b-5p for single and combined diagnosis of prostate cancer were 0.780,0.760,0.763,0.801,and 0.932,respectively.The results of logistic regression analysis showed that rBF＞50.54 mL/(min·100 g),PS＞28.82 mL/(min·100 g),miR-200b-3p＞1.23 were independent risk factors affecting the occurrence of prostate cancer(P＜0.05);MiR-181b-5p＜0.90 is a protective factor affecting the occurrence of prostate cancer(P＜0.05).[Conclusion]The combination of MSCT perfusion imaging parameters and serum miR-200b-3p and miR-181b-5p detection can provide reliable basis for the differential diagnosis of BPH and prostate cancer.
万方数据
维普
