Anesthetic Effect of Dexmedetomidine in Elderly Patients with Intertrochanteric Femur Fractures and its Impact on Postoperative Cognitive Function
[Objective]To investigate the anesthetic effects of dexmedetomidine in elderly patients undergoing surgery for intertrochanteric femur fractures and its impact on postoperative cognitive function.[Methods]In this study,78 elderly patients undergoing surgery for intertrochanteric femur fractures were randomly divided into two groups:the control group received propofol anesthesia and sedation,while the observation group received dexme-detomidine anesthesia and sedation.Comparisons were made between the two groups in terms of surgery duration,time for sedative effect to begin,and time to recover from anesthesia;heart rate and mean arterial pressure at pre-anesthesia(T0),10 minutes after anesthesia(T1),end of surgery(T2),and 1 hour post-surgery(T3);Mini-Mental State Examination(MMSE)scores before surgery and 3 days after surgery;levels of serum norepinephrine(NE),cortisol(COR),malondialdehyde(MDA),and superoxide dismutase(SOD)before and 3 days after sur-gery.[Results]There was no significant difference in surgery duration between the two groups(P＞0.05).The onset time of sedation and recovery time after surgery in the observation group were shorter than those in the con-trol group(P＜0.05).The heart rate and mean arterial pressure at T1,T2,and T3 were lower in the observation group compared to the control group(P＜0.05).Three days post-surgery,there was no significant difference in MMSE scores in the observation group compared to pre-surgery(P＞0.05),while the control group showed a decrease in MMSE scores compared to pre-surgery(P＜0.05).The MMSE scores of 3 days post-surgery in the observation group were higher than those in the control group(P＜0.05).Three days post-surgery,the levels of serum NE,COR,MDA,and SOD in the observation group were lower than those in the control group(P＜0.05).[Conclusion]Dexmedetomidine anesthesia in elderly patients undergoing surgery for intertrochanteric femur fractures can reduce cognitive function impairment.And it is safe and reliable.
万方数据
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