The Levels and Significance of CL,phIGFBP-1,fFN,and Vaginal Microbial Metabolites in Preterm Pregnant Women
[Objective]To investigate the expression levels and significance of hyperphosphorylated insulin-like growth factor binding protein-1(phIGFBP-1),fetal fifinexin(fFN),cervical tube length(CL)and vaginal microbial metabolites in cervical secretions in preterm pregnant women.[Methods]A total of 92 non-full-term single pregnant women with contrac-tions admitted to our hospital from September 2020 to October 2021 were selected and divided into preterm group(n=50)and full-term group(n=42)according to pregnancy outcomes.The positive rates of phIGFBP-1,fFN,CL and vagi-nal microbial metabolites in cervical secretions of the two groups were compared.The correlation among CL,fFN and phIGFBP-1 was analyzed.The predictive efficacy of phIGFBP-1,fFN,and CL in pregnant women with premature delivery was evaluated.[Results]The levels of phIGFBP-1 and fFN from cervical secretions in preterm delivery group were signifi-cantly higher than those in full-term delivery group(P＜0.05),while the level of CL was significantly lower than that in full-term delivery group(P＜0.05).There was a negative correlation of phIGFBP-1 and fFN with CL in cervical secretions(r=-0.320,-0.387,P＜0.05).There were no significant differences in the positive rates of vaginal microbial metabo-lites hydrogen peroxide(H2O2),leucocyte esterase(LE)and sialidase(SNA)between preterm and full-term groups(P＞0.05).The area under receiver operating characteristic(ROC)curve of phIGFBP-1,fFN,CL and their combination for predicting preterm birth were 0.721,0.757,0.841 and 0.976,respectively.[Conclusion]Compared to full-term pregnant women,the levels of phIGFBP-1 and fFN in preterm pregnant women were significantly higher,CL was lower,and vaginal microbial metabolites were not significantly different.The phIGFBP-1,fFN and CL have a good predictive effect on preterm delivery.
Infant,PrematureVagina/MIPregnant WomenInsulin-Like Growth Factor Binding Protein 1Fibronectins
万方数据
维普
