Efficacy of Dual Antiplatelet Therapy in Patients with Acute Cerebral Infarction and H-type Hyper-tension
[Objective]To investigate the efficacy of dual antiplatelet therapy in patients with acute cerebral infarction(ACI)associated with H-type hypertension.[Methods]A total of 100 patients with H-type hypertension related ACI,who received treatment in our hospital,were randomly divided into an observation group and a control group,with 50 pa-tients in each group.Both groups received conventional ACI treatment.The control group was treated with aspirin enteric-coated tablets for antiplatelet therapy,while the observation group received a combination of clopidogrel hydrogen sulfate tablets in addition to the control group's treatment.Both groups maintained the treatment for 8 weeks.The NIH Stroke Scale(NIHSS)scores before and after treatment,the modified Rankin Scale(mRS)scores after treatment,platelet-relat-ed parameters,clinical efficacy,and drug-related adverse events were compared between the two groups.[Results]After treatment,the NIHSS scores of both groups were significantly lower than before treatment(P＜0.05),and the observa-tion group had even lower scores than the control group(P＜0.05).The total effective rate of treatment in the observa-tion group was higher than that in the control group(P＜0.05).The mRS scores of patients in the observation group were lower than those in the control group after treatment(P＜0.0 5).Compared with before treatment,the levels of ho-mocysteine(Hcy),mean platelet volume(MPV),and platelet distribution width(PDW)significantly decreased in both groups after treatment(P＜0.05),and the levels of Hcy,MPV,and PDW in the observation group were significantly lower than those in the control group after treatment(all P＜0.05).There was no significant difference in the total inci-dence of bleeding between the observation group and the control group(P＞0.05).[Conclusion]The combination of as-pirin and clopidogrel hydrogen sulfate tablets for the treatment of ACI patients with concurrent H-type hypertension can reduce neurological deficits,improve the treatment effective rate,and is relatively safe.
万方数据
维普
