Influencing Factors of Chronic Cardiotoxicity in Patients with Malignant Tumors Treated with An-thracycline Chemotherapy
[Objective]To explore the influencing factors of chronic cardiotoxicity in patients with malignant tumors treated with anthracycline chemotherapy.[Methods]The clinical data of 64 patients with malignant tumors treated with anthracyclines in two hospital were collected.According to whether the patients had chronic cardiotox-icity within 1 year of chemotherapy,they were divided into toxic group(25 cases)and non-toxic group(39 cases).The baseline data,ECG abnormalities,cardiac troponin Ⅰ(cTnⅠ),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH)levels of patients in the two groups were compared.The influencing factors of chronic car-diotoxicity in patients were analyzed by using receiver operating characteristic(ROC)curve and multivariate logis-tic regression.[Results]The levels of cTnⅠ,CK-MB and LDH in the toxic group were higher than those in the non-toxic group,and the incidence of ECG abnormalities in the toxic group was higher than that in the non-toxic group(P＜0.05).ROC analysis showed that cTnⅠ,CK-MB and LDH could be used to evaluate the occurrence of chronic cardiotoxicity in patients,and the areas under the curve were 0.746,0.889 and 0.785,respectively(P＜0.05).Multivariate logistic regression analysis confirmed that cTnⅠ＞84.430 ng/mL,CK-MB＞28.692 IU/L,LDH＞203.292 IU/L,ST-T segment changes,T wave abnormalities,sinusachycardia,atrioventricular block were the risk factors of chronic cardiotoxicity(P＜0.05).[Conclusion]cTnⅠ＞84.430 ng/mL,ST-T segment changes,CK-MB＞28.692 IU/L,LDH＞203.292 IU/L,T wave abnormalities,sinus tachycardia,atrioventricular block are the risk factors of chronic cardiotoxicity in patients treated with anthracycline chemotherapy,which can provide a reliable reference for early clinical intervention.
Neoplasms/DTAnthracyclines/TOCardiotoxicityRoot Cause Analysis
万方数据
维普
