The Clinical Value of miRNA-208b in Predicting Left Ventricular Remodeling after AMI
[Objective]To explore the clinical value of miRNA-208b(miR-208b)in predicting left ventricular remode-ling after acute myocardial infarction(AMI).[Methods]A total of 167 AMI patients admitted to our hospital from Novem-ber 2018 to September 2020 were selected,and they were divided into a remodeling group(n=62)and a non remodeling group(n=105)based on whether there was left ventricular remodeling during follow-up.The clinical indicators and ex-pression of miR-208b,as well as the correlation between miR-208b and left ventricular remodeling,were analyzed in two groups of patients.The receiver operating characteristic(ROC)curve analysis was used to evaluate the value of miR-208b in left ventricular remodeling in AMI patients.[Results]The final left ventricular end diastolic volume(LVEDV),left ven-tricular end diastolic volume increase(LVEDV),low-density lipoprotein cholesterol(LDL-C),cardiac troponin Ⅰ(cTnⅠ),and brain natriuretic peptide(BNP)levels of patients in the reconstruction group were higher than those in the non recon-struction group,and the expression level of miR-208b was lower than that in the non reconstruction group,with statistical significance(P＜0.05).Pearson correlation analysis showed that miR-208b was negatively correlated with BNP and final LVEDV(P＜0.05),and positively correlated with cTnⅠ(P＜0.05).ROC curve analysis showed that miR-208b had a high value in predicting left ventricular remodeling after AMI,with an area under the curve(AUC)(95％CI)of 0.80(0.73-0.87)and an optimal diagnostic threshold of 3.17.Binary logistic regression analysis showed that miR-208b,cTnⅠ,LVEDV,and BNP were closely related to left ventricular remodeling(P＜0.05).[Conclusion]miR-208b is a potential clinical indicator for diagnosing left ventricular remodeling after AMI,and clinical physicians can estimate the risk of left ventricular remodeling in AMI patients based on miR-208b expression.
万方数据
维普
