The Clinical Efficacy of Lamotrigine Combined with Topiramate in the Treatment of Children with Epilepsy and its Impact on Cognitive Function and Neurotrophic Factor Levels in Patients
[Objective]To explore the clinical efficacy of lamotrigine combined with topiramate in the treatment of chil-dren with epilepsy and its impact on cognitive function and neurotrophic factor levels in patients.[Methods]A retrospective analysis was conducted on the clinical data of 56 children with epilepsy admitted to our hospital from February 2021 to De-cember 2022.According to different treatment plans,the children were divided into a control group(treated with lamotrigi-ne)and an observation group(treated with lamotrigine and topiramate),with 28 cases in each group.Two groups were compared in terms of clinical efficacy,electroencephalogram efficacy,pre-treatment and post-treatment seizure status,neu-rokine levels[neuropeptide Y(NPY),insulin-like growth factor-1(IGF-1),brain-derived neurotrophic factor(BDNF),intercellular adhesion molecule-1(ICAM-1)],cognitive function[Wechsler Intelligence Scale(WISC-1V)score],anxiety and depression[Hamilton Anxiety Scale(HAMA)and Depression Scale(HAMD)score].[Results]The clinical effective rate and total effective rate of EEG in the observation group were higher than those in the control group,and the difference was statistically significant(P＜0.05).After treatment,the frequency and duration of seizures in both groups were lower than before treatment,and the observation group was lower than the control group,with a statistically significant difference(P＜0.05).After treatment,the WISC-Ⅳ score of the observation group was higher than that of the control group,and the HAMA and HAMD scores were lower than those of the control group(P＜0.05).After treatment,the serum levels of NPY,IGF-1,BDNF,and ICAM-1 in both groups were lower than before treatment,and the observation group was lower than the control group,with statistical significance(P＜0.05).[Conclusion]The combination of lamotrigine and topiramate has a good clinical efficacy in the treatment of pediatric epilepsy,which can reduce the number of seizures,pro-mote neurological function recovery,improve cognitive function,and alleviate anxiety and depression.
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