Clinical Efficacy of Rh-bFGF Preparation Combined with Sodium Hyaluronate Patch in the Treat-ment of Traumatic Tympanic Membrane Perforation
[Obj ective]To explore the clinical effect of recombinant human basic fibroblast growth factor(Rh-bFGF)preparation combined with sodium hyaluronate patch in the treatment of traumatic tympanic membrane perforation.[Meth-ods]A total of 82 patients(82 ears)with traumatic tympanic membrane perforation admitted to Yulin City Hospital of Tra-ditional Chinese Medicine from June 2020 to June 2022 were selected and randomly divided into a control group and an ob-servation group using a random number table method,with 41 cases in each group.The control group received treatment with sodium hyaluronate patches,while the observation group received treatment with Rh-bFGF formulation combined with sodium hyaluronate patches.The healing of tympanic membrane perforation in patients was evaluated after 2 weeks and 4 weeks of treatment,respectively;We compared the air bone conduction difference and air guided hearing valve between two groups before treatment and 3 months after treatment;We also compared the severity of tinnitus and ear pain between two groups of patients after 4 weeks of treatment.[Results]The healing rate of the tympanic membrane in the observation group was higher than that in the control group after 2 weeks and 4 weeks of treatment(P＜0.05).After 3 months of treat-ment,the air bone conduction difference and air guided hearing valve in both groups were lower than before treatment,and the observation group was lower than the control group(P＜0.05).After 4 weeks of treatment,the severity of tinnitus and ear pain in both groups was lower than before treatment,and the observation group was lower than the control group(P＜0.05).[Conclusion]The combination of Rh-bFGF preparation and sodium hyaluronate patch in the treatment of trau-matic tympanic membrane perforation can help improve the patient's hearing level and tympanic membrane healing rate,and improve symptoms of tinnitus and ear pain.
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