Clinical Efficacy of High Frequency Oscillatory Ventilation Combined with Budesonide Atomization Inhalation in the Treatment of Neonatal Severe Pneumonia
[Objective]To investigate the clinical effect of high frequency oscillatory ventilation combined with budes-onide atomization inhalation in the treatment of neonatal severe pneumonia.[Methods]A total of 81 cases of neonatal se-vere pneumonia in our hospital from September 2016 to June 2021 were selected and randomly divided into observation group(n=41)and control group(n=40).The control group was treated with high-frequency oscillatory ventilation on the basis of basic treatment,and the observation group was treated with budesonide atomization inhalation on the basis of the control group.The disappearance time of pulmonary wet rales,cough,fever,asthma and other symptoms and the time of high-frequency oscillatory ventilation were recorded in the two groups after treatment.The pulmonary function in-dexes[peak expiratory flow rate(PEF),peak volume ratio(VPEF/VE),and peak time ratio(TPTEF/TE)]and hema-tological indexes[serum Clara cell protein 16(CC16),type Ⅱ alveolar surface antigen 6(KL-6)]before and 10 days after treatment were compared between the two groups.The occurrence of adverse reactions during treatment was recorded.[Results]The disappearance time of wet rales,cough,asthma and fever in the observation group were shorter than those in the control group,and the high-frequency oscillation ventilation time in the observation group was shorter than that in the control group,with statistical significance(P＜0.05).After treatment,the levels of TPTEF/TE,PEF and VPEF/VE in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,with statistical significance(P＜0.05);The serum levels of KL-6 and CC16 in the two groups were lower than those before treatment,and the observation group was lower than that in the control group,the differ-ence was statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions be-tween the two groups(P＞0.05).[Conclusion]High frequency oscillatory ventilation combined with budesonide atomiza-tion inhalation therapy can effectively shorten the time of clinical symptoms improvement and high frequency oscillatory ventilation in children with severe pneumonia,improve the lung function of children,and reduce the serum levels of KL-6 and CC16,with good safety.
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维普
