Application of Liver Stiffness,Serum CER and AST Levels in Evaluating Liver Fibrosis of Patients with ALT Elevated Hepatitis B
[Objective]To explore the value of ultrasound in detecting liver stiffness(LSM),serum ceruloplasmin(CER)and aspartate aminotransaminase(AST)in evaluating liver fibrosis of patients with mild elevation of alanine amin-otransferase(ALT).[Methods]From June 2020 to June 2022,100 patients with hepatitis B showing slightly elevated ATL admitted to our hospital were divided into non-fibrosis group(n=10)and fibrosis group(n=90)according to the stage of liver fibrosis.According to the severity of liver fibrosis,patients were divided into severe fibrosis group(n=42),moderate fibrosis group(n=36),and mild fibrosis group(n=12).The value of ALT,albumin(ALB),AST and CER,LSM was compared in different groups of patients.The ROC curve of subjects was drawn to analyze the evalu-ation value of CER,AST,LSM on liver fibrosis in hepatitis B patients with mild elevation of ALT.[Results]There was no statistically significant difference in ALT and ALB between the two groups of fibrosis and non-fibrosis patients(P＞0.05);The AST and LSM of the fibrosis group were higher than those of the non-fibrosis group,and the CER of the fi-brosis group was lower than that of the non-fibrosis group,with statistical significance(P＜0.05).ROC curve analysis showed that the area under the curve of AST,CER and LSM for evaluating liver fibrosis in hepatitis B patients with slightly elevated ATL was 0.914,0.616 and 0.946,respectively(P＜0.05).The CER of the severe fibrosis group,the moderate fibrosis group,and the mild fibrosis group gradually increased,and the difference was statistically significant(P＜0.05);The AST and LSM gradually decreased in the severe fibrosis group,moderate fibrosis group,and mild fibrosis group,and the difference was statistically significant(P＜0.05).[Conclusion]There are differences in AST,CER and LSM in patients with hepatitis B with slightly elevated ATL at different levels of fibrosis.AST,CER and LSM have cer-tain evaluation value for liver fibrosis and can be used for early diagnosis or evaluation of liver fibrosis in such patients.
万方数据
维普
