The Relationship among Serum 25-Hydroxyvitamin D,Low-Density Lipoprotein Cholesterol and Hy-pertension Grading in Hypertensive Patients
[Objective]To explore the relationship among serum 25-hydroxyvitamin D[25-(OH)D]level,low-density lipoprotein cholesterol(LDL-C)level,and the classification of hypertension in hypertensive patients.[Methods]According to the hypertension grading standards,371 hypertensive patients treated in our hospital were divided into grade 1 hyperten-sion(120 cases),grade 2 hypertension(124 cases)and grade 3 hypertension(127 cases).While 391 healthy individuals undergoing physical examinations at our hospital during the same period were selected as the control group.General infor-mation of all participants was collected.Fasting blood glucose(FBG),triglycerides(TG),total cholesterol(TC),creati-nine(Cr),high-density lipoprotein cholesterol(HDL-C),25-(OH)D,and LDL-C levels were measured.Correlation anal-ysis was conducted between 25-(OH)D and LDL-C levels.Multifactorial logistic regression analysis was used to analyze the risk factors influencing the occurrence of hypertension.[Results]Compared to the control group,the hypertensive group showed significantly higher levels of body mass index(BMI),smoking proportion,systolic blood pressure(SBP),diastolic blood pressure(DBP),FBG,and LDL-C(P＜0.05);while the level of 25-(OH)D in the hypertensive group was signifi-cantly lower than that in the control group(P＜0.05).The BMI,FBG,and LDL-C of hypertensive patients increased with the grade of hypertension(P＜0.05),meanwhile the level of 25-(OH)D decreased with the grade of hypertension(P＜0.05).The correlation analysis showed that patients'BMI,smoking,SBP,DBP,and FBG were positively correlated with serum LDL-C level(P＜0.05)and negatively correlated with 25-(OH)D level(P＜0.05).Multifactorial logistic re-gression analysis showed that FBG and LDL-C were independent risk factors for hypertension(P＜0.05),while HDL-C and 25-(OH)D were protective factors against hypertension(P＜0.05).[Conclusion]Low level of 25-(OH)D and high level of LDL-C in hypertensive patients are closely related to the blood pressure classification(grades)of hypertension.
万方数据
维普
