Effect of Pre-Chemotherapy Blood Lipid Levels on Liver Dysfunction after Chemotherapy in Pa-tients with Esophageal Cancer
[Objective]To explore the impact of blood lipid levels before the first chemotherapy on liver dysfunction after chemotherapy in patients with esophageal cancer.[Methods]Eighty-four esophageal cancer patients with normal liver function undergoing their first chemotherapy were divided into two groups based on pre-chemotherapy blood lipid levels:the abnormal lipid group(n=49)and the normal lipid group(n=35).The occurrence of liver dysfunction after chemotherapy was compared between the two groups.Logistic re-gression analysis was used to assess the impact of pre-chemotherapy blood lipid levels on post-chemotherapy liver dysfunction.[Results]Before chemotherapy,there were no significant differences in serum alanine amin-otransferase(ALT),aspartate aminotransferase(AST),and alkaline phosphatase(ALP)levels between the abnormal and normal lipid groups(P＞0.05).Patients in the abnormal lipid group had higher levels of total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C)(P＜0.05),and low-er level of high-density lipoprotein cholesterol(HDL-C)compared to the normal lipid group(P＜0.05).The occurrence rate of liver dysfunction after chemotherapy was 44.90％(22/49)in the abnormal lipid group,which was higher than that in the normal lipid group at 20.00％(7/35)(P＜0.05).After chemotherapy,pa-tients with liver dysfunction had higher serum TC,TG,and LDL-C levels,and lower HDL-C level compared to those with normal liver function(P＜0.05).Serum TC,TG,LDL-C,and HDL-C were independent risk factors for liver dysfunction after chemotherapy in patients with esophageal cancer(P＜0.05).[Conclusion]Patients with esophageal cancer who have abnormal blood lipid parameters before the first chemotherapy are at a higher risk of developing liver dysfunction afterwards.Clinicians should strengthen preventive measures.
万方数据
维普
