The Effect of Zishen Runfeifang in Combined with Chemotherapy on Clinical Efficacy with Ad-vanced Lung Cancer Exhibiting Both Qi and Yin Deficiencies
[Objective]To explore the efficacy of Zishen Runfeifang in combined with chemotherapy in pa-tients with advanced lung cancer exhibiting both Qi and Yin deficiencies.[Methods]Eighty patients with ad-vanced lung cancer exhibiting both Qi and Yin deficiencies,who received treatment in our two hospitals,were randomly divided into a chemotherapy group and a combination group,with 40 patients in each group.The chemotherapy group received conventional lung cancer chemotherapy,while the combination group received Zishen Runfeifang orally in addition to the chemotherapy.The efficacy,time to disease progression(TTP),1-year survival rate,1-year progression-free survival(PFS)rate,improvements in Traditional Chinese Medicine symptom scores,and Karnofsky Performance Scale(KPS)scores before and after treatment,as well as the occurrence of bone marrow suppression,were compared between the two groups.[Results]The total effective rate(RR)in the combination group was 37.5％(15/40)and the disease control rate(DCR)was 82.5％(33/40),whereas the chemotherapy group had an RR of 27.5％(11/40)and a DCR of 70.0％(28/40).The differ-ences between the groups were not statistically significant(P＞0.05).The TTP in the chemotherapy group was 6.5(4.2-8.4)months,with a 1-year survival rate of 30.0％(12/40),and a 1-year PFS rate of 85.0％(34/40);the combination group had a TTP of 7.2(5.5-9.3)months,a 1-year survival rate of 35.0％(14/40),and a 1-year PFS rate of 87.5％(35/40).The differences between the two groups were not statistically significant(P＞0.05).Compared to before treatment,both groups showed a significant reduction in Tradi-tional Chinese Medicine symptom scores after treatment,with more significant reductions in the combination group(P＜0.05).After treatment,the stability rate of KPS scores in the combination group was 90.00％(36/40),significantly higher than the 70.00％(28/40)in the chemotherapy group(P＜0.05).The total occur-rence rate of bone marrow suppression in the combination group was 17.5％(7/40),lower than 42.5％(17/40)in the chemotherapy group.[Conclusion]Zishen Runfeifang combined with chemotherapy can effectively im-prove patients quality of life and reduce the occurrence rate of bone marrow suppression.
万方数据
维普
