The Effect of Cisapride Combined with Hemoperfusion on Gastrointestinal Symptoms and Gas-trointestinal Hormone Levels in CRF Maintenance Hemodialysis Patients
[Objective]To explore the effects of cisapride assisted blood perfusion therapy on gastrointestinal symptoms and gastrointestinal hormone levels in maintenance hemodialysis patients with chronic renal failure(CRF).[Methods]A retrospective analysis was conducted on the clinical data of 72 patients with CRF admitted to our hospi-tal from February 2021 to January 2023.According to the treatment method,they were divided into an observation group and a control group,with 36 cases in each group.Both groups received maintenance hemodialysis treatment,the control group received hemoperfusion treatment,and the observation group received cisapride treatment on the ba-sis of the control group.After 2 weeks of treatment,renal function(Scr),urea nitrogen(BUN),glomerular filtra-tion rate(GFR),gastrointestinal symptoms,gastrointestinal hormones[somatostatin(SS),motilin(MOT),vaso-active intestinal peptide(VIP)],serum fibroblast growth factor 23(FGF-23),calcitonin gene related peptide(CGRP),tumor necrosis factor alpha(TNF-α)levels,and incidence of adverse reactions were compared between the two groups.[Results]After treatment,Scr and BUN of two groups decreased compared to before treatment,EGER increased compared to that before treatment(P＜0.05);There was no statistically significant difference between Scr,BUN and eGER in the two sets(P＞0.05).After treatment,the scores of acid reflux,nausea and vomiting,bloating,belching,and constipation in both groups were lower than those before treatment,and the observation group was lower than the control group(P＜0.05).After treatment,The level of serum MOT and SS in the obser-vation group was lower than that before treatment and that in the control group,VIP was higher than that before treatment and that in the control group(P＜0.05).After treatment,The levels of serum FGF-23 CGRP and TNF-αin two groups were lower than those before treatment,and the observation group was lower than the control group(P＜0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).[Conclusion]Cisapride assisted hemoperfusion therapy for CRF maintenance hemodialysis can regulate gastrointestinal hormone levels,improve gastrointestinal symptoms,alleviate inflammatory damage,and has high safety.
万方数据
维普
