Effects of Sevoflurane Combined Anesthesia on Hemodynamics and Pain Factors in Patients Undergoing Gy-necological Laparoscopic Surgery
[Objective]To investigate the effects of sevoflurane combined anesthesia on hemodynamics and pain factors in patients undergoing gynecological laparoscopic surgery.[Methods]There were 86 patients with gynecological diseases treated by laparoscopic surgery in our hospital and random divided into the observation group and the control group(n=43).The control group received propofol combined anesthesia,and the observation group received sevoflurane combined an-esthesia.The anesthesia effects,heart rate(HR),mean arterial pressure(MAP)and other hemodynamic indicators before induction(T0),intubation(T1),intubation 5 min(T2),skin incision(T3),post-pneumoperitoneum(T4),and extuba-tion(T5)were compared between the two groups.Serum levels of pain factors such as 5-HT,PGE2,β-endorphin(β-EP)and substance P(SP)at 6 h,12 h and 24 h postoperatively,and the occurrence of postoperative adverse reactions of the two groups was compared as well.[Results]There was no difference in anesthesia time between the two groups(P＞0.05).The recovery time of spontaneous breathing,eye opening time,language response time,recovery time of orientation and extubation time in observation group were shorter than those in control group(P＜0.05).At T3,HR of observation group was higher than that of control group at the same point(P＜0.05).At T2,T3 and T4,the MAP of observation group was higher than that of control group(P＜0.05).There were no differences in HR and MAP between the two groups at other time points(P＞0.05).There were no differences in the incidence of 5-HT,PGE2,β-EP,SP and adverse reactions between two groups before and after operation(P＞0.05).[Conclusion]sevoflurane combined anesthesia can maintain hemodynamic stability,promote postoperative resuscitation and effectively regulate pain factors in patients under-going gynecological laparoscopic surgery,and the incidence of adverse reactions is low.
万方数据
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