Detection and Clinical Significance of Peripheral Blood miRNA-218 and Survivin Gene Expres-sion in Patients with Acute Myeloid Leukemia
[Objective]To investigate the detection and clinical significance of peripheral blood miRNA-218 and survivin gene expression in patients with acute myeloid leukemia(AML).[Methods]Eighty-six AML pa-tients admitted to our hospital were selected as the observation group,and 20 healthy individuals undergoing physical examination in our hospital during the same period were selected as the control group.The relative ex-pression levels of miRNA-218 and survivin in peripheral blood were compared between the two groups.The clinical data of the observation group were statistically analyzed to determine the relationship of the levels of miRNA-218 and survivin with the clinical efficacy and survival time of the patients.[Results]The level of miR-NA-218 in the observation group was lower than that in the control group,while the level of the survivin gene was higher than that in the control group(both P＜0.05).Among the observation group,patients with WBC≥30X109/L had lower level of miRNA-218 and higher level of survivin compared to patients with WBC＜30 X109/L,with statistically significant differences(P＜0.05).The miRNA-218 level in the remission group was higher than that in the non-remission group,while the survivin level was lower in the remission group compared to the non-remission group(both P＜0.05).The median survival times for the high and the low miRNA-218 expression groups were 17.00 months and 14.00 months,respectively,with statistically signifi-cant differences in the cumulative survival curves between the two groups(P＜0.05).The median survival times for the high and the low survivin expression groups were 18.00 months and 20.00 months,respectively,with statistically significant differences in the cumulative survival curves between the two groups(P＜0.05).[Conclusion]miRNA-218 is lowly expressed and the survivin gene is highly expressed in the peripheral blood of AML patients.Both are important factors associated with poor clinical efficacy and prognosis in AML pa-tients.
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