Correlation of Serum miR-28-3p and miR-23a Levels with Prognosis of Patients with Non-Small Cell Lung Cancer Treated with Radiofrequency Ablation
[Objective]To investigate the correlation between the expression levels of serum miR-28-3p and miR-23a and the prognosis of patients with non-small cell lung cancer(NSCLC)undergoing radiofrequency ablation(RFA)treatment.[Methods]A total of 94 NSCLC patients treated with RFA were included in the study.Based on the survival status of the patients during follow-up,they were divided into a survival group(74 cases)and a deceased group(20 cases).The serum levels of miR-28-3p and miR-23a were compared between the two groups.Spearman correlation was used to assess the relationship between serum miR-28-3p and miR-23a levels and the prognosis of the patients.Receiver operating characteristic(ROC)curves were con-structed to analyze the predictive value of combined detection of serum miR-28-3p and miR-23a levels for pa-tient prognosis.[Results]The serum levels of miR-28-3p and miR-23a in the survival group were lower than those in the deceased group(P＜0.05).Spearman analysis showed that serum miR-28-3p and miR-23a levels were positively correlated with poor prognosis in NSCLC patients(P＜0.05).ROC analysis indicated that the combined detection of serum miR-28-3p and miR-23a levels had a sensitivity of 95.0％and a specificity of 97.3％for predicting patient prognosis,with an area under the curve(AUC)of 0.986,which was superior to the detection of each marker alone(P＜0.05).[Conclusion]The levels of serum miR-28-3p and miR-23a are positively correlated with poor prognosis in NSCLC patients treated with RFA.Combined detection of these two markers has high sensitivity and specificity for predicting patient prognosis.
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