双向孟德尔随机化分析胃癌和肌肉减少症的遗传因果关系
Bidirectional Mendelian Randomization Analysis of Genetic Causal Relationships between Gas-tric Cancer and Sarcopenia
徐宏 1陈鹳颐 2吴晓欣 2李辉 2毛新展2
作者信息
- 1. 中南大学湘雅医学院,湖南 长沙 410000
- 2. 中南大学湘雅二医院骨科,湖南 长沙 410011
- 折叠
摘要
[目的]采用两样本双向孟德尔随机化(MR)分析遗传层面上肌肉减少症与胃癌之间的潜在因果关系.[方法]从公开发布的全基因组关联研究(GWAS)统计数据获取显著性的工具变量(IV)进行两样本MR分析,采用Cochran's Q检验等方法进行敏感性分析保证IV符合三大假设,采用逆方差加权(IVW)等方法评估胃癌和肌肉减少症之间的双向因果关系.[结果]正向MR分析结果显示:胃癌与四肢肌肉质量(ALM)(OR=-0.019,P=0.446)、左手握力(OR=-0.008,P=0.059)、右手握力(OR=-0.010,P=0.220)未发现因果关系(P＞0.05);反向MR分析中也未发现上述指标的因果关系(P＞0.05).[结论]胃癌与肌肉减少症在遗传层面上无直接因果关系.
Abstract
[Objective]To analyze the potential causal relationship between sarcopenia and gastric cancer at the genetic level using two sample bidirectional Mendelian randomization(MR).[Methods]Significant instru-mental variables(IV)were obtained from publicly available genome-wide association studies(GWAS)statistical data for two sample MR analysis.Sensitivity analysis was performed using methods such as Cochran's Q test to ensure that IV met the three major hypotheses.Methods such as inverse variance weighting(IVW)were used to evaluate the bidirectional causal relationship between gastric cancer and sarcopenia.[Results]The positive MR analysis results showed that no causal relationship was found between gastric cancer and limb muscle mass(ALM)(OR=-0.019,P=0.446),left hand grip strength(OR=-0.008,P=0.059),and right hand grip strength(OR=-0.010,P=0.220)(P＞0.05);No causal relationship was found between the above indicators in the reverse MR analysis(P＞0.05).[Conclusion]There is no direct causal relationship between gastric cancer and sarcopenia at the genetic level.
关键词
胃肿瘤/肌减少症/孟德尔随机化分析/遗传Key words
Stomach Neoplasms/Sarcopenia/Mendelian Randomization Analysis/Heredity引用本文复制引用
出版年
2024
NETL
NSTL
万方数据