Bidirectional Mendelian Randomization Analysis of Genetic Causal Relationships between Gas-tric Cancer and Sarcopenia
[Objective]To analyze the potential causal relationship between sarcopenia and gastric cancer at the genetic level using two sample bidirectional Mendelian randomization(MR).[Methods]Significant instru-mental variables(IV)were obtained from publicly available genome-wide association studies(GWAS)statistical data for two sample MR analysis.Sensitivity analysis was performed using methods such as Cochran's Q test to ensure that IV met the three major hypotheses.Methods such as inverse variance weighting(IVW)were used to evaluate the bidirectional causal relationship between gastric cancer and sarcopenia.[Results]The positive MR analysis results showed that no causal relationship was found between gastric cancer and limb muscle mass(ALM)(OR=-0.019,P=0.446),left hand grip strength(OR=-0.008,P=0.059),and right hand grip strength(OR=-0.010,P=0.220)(P＞0.05);No causal relationship was found between the above indicators in the reverse MR analysis(P＞0.05).[Conclusion]There is no direct causal relationship between gastric cancer and sarcopenia at the genetic level.
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