Effectiveness of Etaracog Alfa Combined with Clopidogrel in Treating Elderly Patients with Acute Cerebral Infarction
[Objective]To explore the effectiveness of a combination of Etaracog Alfa injection and clopi-dogrel in treating elderly patients with acute cerebral infarction(ACI).[Methods]A total of 82 elderly ACI pa-tients treated were randomly divided into an observation group and a control group,with 41 patients in each group.The control group received clopidogrel treatment,while the observation group was treated with a com-bination of Etaracog Alfa injection and clopidogrel.The effectiveness of the treatments was compared by meas-uring various factors before and 14 days after treatment.These included the average blood flow velocity during systole(Vm)and peak blood flow(Vs)in the posterior cerebral artery,resistance index(RI),National Institu-tes of Health Stroke Scale(NIHSS)scores,and levels of high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-alpha(TNF-α),glutathione peroxidase(GPx),and malondialdehyde(MDA).[Results]The to-tal effective rate in the observation group was 95.12％(39/41),which was significantly higher than the 80.49％(33/41)in the control group(P＜0.05).After treatment,Vm,Vs,and GPx levels were elevated in both groups,with higher increases in the observation group(P＜0.05).RI,NIHSS scores,and levels of hs-CRP,TNF-α,and MDA were reduced compared to pre-treatment levels,with greater reductions in the obser-vation group(P＜0.05).[Conclusion]The combination of Etaracog Alfa injection and clopidogrel in treating elderly ACI patients effectively improves cerebral hemodynamics,inhibits inflammatory stress damage,re-stores neurological function,and is effective and safe overall.
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