The Predictive Value of Serum Alanine Aminotransferase/Aspartate Aminotransferase Combined with Carcinoembryonic Antigen for Postoperative Prognosis in Patients with Hepatocellular Car-cinoma
[Objective]To investigate the predictive value of serum alanine aminotransferase/aspartate amin-otransferase(ALT/AST)combined with carcinoembryonic antigen(CEA)for postoperative prognosis in patients with hepatocellular carcinoma(HCC).[Methods]Ninety-one HCC patients treated surgically in our hospital were followed up for three years postoperatively.The survival status was recorded,and clinical data of deceased and surviving pa-tients were compared.Factors influencing mortality and the predictive value of serum ALT/AST combined with CEA for prognosis were analyzed.[Results]Of the 91 patients,9 were lost to follow-up.Among the remaining 82 patients,28 died and 54 survived.The proportion of poorly differentiated tumors,Child-Pugh grade B and distant metastasis in the deceased group were higher than those in the surviving group(P＜0.05).The serum CEA levels in the deceased group were higher than that in the surviving group(P＜0.05).The ALT/AST ratio in the deceased group was lower than that in the surviving group(P＜0.05).Distant metastasis,ALT/AST,and CEA were independent risk factors for mortality(OR=4.158,4.039,and 4.067,respectively,P＜0.05).The specificity and area under the curve(AUC)for predicting postoperative mortality in HCC patients using serum ALT/AST combined with CEA were 96.30％and 0.946,respectively,indicating higher predictive value than using ALT/AST or CEA alone.[Conclusion]Clinical detection of serum ALT/AST and CEA can serve as sensitive indicators for predicting postoperative mortality in HCC patients,with combined detection offering higher predictive value.
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