Expression of MTA1 and VEGF-C in Lung Cancer Tissue and Correlation with Clinical Staging and Prognosis of Patients
[Objective]To analyze the expression levels of metastasis related gene 1(MTA1)and vascular endothelial growth factor C(VEGF-C)in lung cancer tissue and their correlation with clinical staging and prognosis of patients.[Methods]Retrospective analysis of clinical data from 85 patients diagnosed with lung cancer in our hospital.All lung cancer tissues and adjacent tissues of the patients were collected as pathological specimens,and the positive expression rates of MTA1 and VEGF-C were detected using immunohistochemis-try.Meanwhile,the expression levels of MTA1 and VEGF-C was detected by PCR fluorescence quantification method.The positive expression rates of MTA1 and VEGF-C were compared among patients with different clinical pathological parameters and prognostic outcomes.[Results]The positive rates of MTA1 and VEGF-C in lung cancer tissues were higher than those in adjacent tissues(P＜0.05).And the expression levels of both proteins of cancer tissues were also higher than those of the adjacent tissues(P＜0.05).The positive rates and expression levels of MTA1 and VEGF-C in patients with TNM stages,low differentiation,tumor diame-ter＞5 cm,lymph node metastasis,vascular invasion,and poor prognosis showed an upward trend(P＜0.05).The cumulative progression free survival rate at 24 months in the MTA1 positive expression group was lower than the negative expression group(P＜0.05).The survival rate of the VEGF-C positive expression group was lower than the negative expression group,and the difference was significant(P＜0.05).The ex-pression of MTA1 and VEGF-C in lung cancer tissue is closely related to tumor TNM staging,differentiation degree,tumor diameter,lymph node metastasis,vascular invasion,and prognosis(P＜0.05).[Conclusion]MTA1 and VEGF-C are often positively expressed in lung cancer tissues,and their expression levels can serve as important factors for evaluating pathological features such as tumor staging,diameter,and prognosis to a certain extent.It is worth further exploration in clinical practice.
万方数据
维普
