Changes in Serum Levels of Perilipin-5,RBP-4,FGF-23 in Patients with Coronary Heart Disease and their Correlation with the Degree of Coronary Artery Stenosis
[Objective]To investigate the changes in serum levels of perilipin-5,retinol binding protein-4(RBP-4),and fibroblast growth factor-23(FGF-23)in patients with coronary heart disease and their correlation with the degree of coronary artery stenosis.[Methods]A total of 142 patients with coronary heart disease admitted to two hospitals from May 2020 to January 2023(observation group)were selected,and 100 healthy volunteers who underwent physical examinations during the same period were selected as the control group.We compared the changes in serum levels of perilipin-5,RBP-4,and FGF-23 between two groups,and compared the levels of perilipin-5,RBP-4,and FGF-23 in patients with different types of coronary heart disease,number of lesion branches,and degree of stenosis.We analyzed the correlation between ser-um levels of perilipin-5,RBP-4,and FGF-23 and the number of lesion branches and degree of stenosis,as well as their di-agnostic value for the degree of stenosis.[Results]The serum levels of RBP-4 and FGF-23 in the observation group were higher than those in the control group,and the serum level of perilipin-5 was lower than that in the control group,with sta-tistical significance(P＜0.05).The serum levels of perilipin-5 in patients with stable angina are higher than those in pa-tients with unstable angina and acute myocardial infarction,while the serum levels of RBP-4 and FGF-23 are lower than those in patients with unstable angina and acute myocardial infarction,and the differences are statistically significant(P＜0.05).The serum levels of perilipin-5 in patients with mild stenosis were higher than those in patients with moderate and severe stenosis,while the serum levels of RBP-4 and FGF-23 were lower than those in patients with moderate and severe stenosis,and the differences were statistically significant(P＜0.05).The serum level of perilipin-5 in patients with single vessel disease is higher than that in patients with double vessel disease and multi vessel disease,while the serum levels of RBP-4 and FGF-23 are lower than those in patients with double vessel disease and multi vessel disease,and the differences are statistically significant(P＜0.05).Spearman correlation analysis showed that serum perilipin-5 is negatively correlated with the number and degree of stenosis of the lesion,while RBP-4 and FGF-23 are positively correlated with the number and degree of stenosis of the lesion.The analysis of the working characteristic curve of the subjects showed that the AUC of the combined diagnosis of perilipin-5,RBP-4,and FGF-23 for the degree of coronary heart disease stenosis was 0.819,which was better than the diagnosis of each single indicator(P＜0.05).[Conclusion]The changes in serum levels of perili-pin-5,RBP-4,and FGF-23 are significantly correlated with the condition of coronary heart disease patients.The combined diagnosis of the three can help achieve disease risk stratification.
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