Relationship of GTPase-Activating Protein SH3 Domain-Binding Protein 1 Expression in Non-Small Cell Lung Cancer with Radiotherapy Efficacy
[Objective]To investigate the expression of GTPase-activating protein SH3 domain-binding protein 1(G3BP1)in tissues of patients with non-small cell lung cancer(NSCLC)and its relationship with the efficacy of radiotherapy.[Methods]The expression levels of G3BP1 protein were measured in the tissues of 133 NSCLC patients.The relationship between G3BP1 expression and NSCLC clinicopathological parameters as well as radiotherapy efficacy was analyzed.[Results]There were statistically significant differences in G3BP1 protein levels among NSCLC tissues with different tumor diameters,TNM stages,and lymph node metastasis(P＜0.05).The G3BP1 protein level in the radiotherapy effective group was lower than that in the ineffective group,with a statistically significant difference(P＜0.05).The area under the receiver operating characteris-tic(ROC)curve(AUC)for evaluating the efficacy of G3BP1,optimal cutoff point,sensitivity,and specificity were 0.802,2.33,86.54％,and 61.73％,respectively.Logistic multivariate regression analysis showed that tumor diameter,TNM stage,lymph node metastasis,acute radiation pneumonitis,and G3BP1 level were in-dependent risk factors affecting the efficacy of radiotherapy in NSCLC(P＜0.05).[Conclusion]G3BP1 is re-lated to tumor diameter,TNM stage,and lymph node metastasis in NSCLC.Its level can provide a reference for evaluating the efficacy of radiotherapy in patients.
万方数据
维普
