Changes and Clinical Significance of Coagulation Function in Severe Preeclamps Complicated with HELLP Syndrome
[Objective]To analyze the changes of coagulation function and its clinical significance in pa-tients with severe preeclampsia(SPE)complicated with HELLP syndrome.[Methods]Ninety-eight SPE pa-tients admitted to our hospital from January 2018 to December 2022 were selected and divided into group A(with HELLP syndrome,n=30)and group B(without HELLP syndrome,n=68)according to whether the patients would develop HELLP syndrome during hospitalization.Coagulation indexes[fibrinogen(FIB),pro-thrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen degradation product(FDP),D-dimer(D-D)],interleukin(IL-6)and C-reactive protein(CRP)were compared between the two groups at admission.Multiple Logistic regression was used to analyze the influencing factors of SPE complicated with HELLP syndrome.[Results]There were no significant differences in pregnant type,age,gestational week,body weight,respiratory rate(RR),systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),mean arterial pressure(MAP),creatinine(Scr)and blood urea nitrogen(BUN)between the two groups(P＞0.05).The PT and APTT measurements in group A were longer than those in group B,the lev-els of D-D,FDP,IL-6 and CRP were higher than those in group B,and the levels of FIB and red blood cell(RBC)count were lower than those in group B,with statistical significance(P＜0.05).Multivariate Logistic regression analysis showed that PT,APTT,D-D,FDP,FIB and RBC were the influencing factors of HELLP syndrome in SPE patients(P＜0.05).[Conclusion]Abnormal RBC,PT,APTT,FIB,D-D and FDP are risk factors for HELLP syndrome in SPE patients.Monitoring the changes of the above indexes can provide refer-ences for clinicians to evaluate the condition,efficacy and prognosis of SPE patients with HELLP syndrome.
万方数据
维普
