Predictive Value of Uterine Artery Pulse Index Combined with Serum β-HCG Level in Late-Onset Fetal Intrauterine Growth Restriction in the Second Trimester
[Objective]To investigate the value of uterine artery pulsation index(PI)combined with serum β-subunit human chorionic gonadotropin(β-HCG)level in predicting intrauterine growth restriction in late-onset fetuses during the second trimester.[Methods]A total of 179 pregnant women were selected from Xi'an People's Hospital(Xi'an Fourth Hos-pital)from January 2019 to December 2023.According to the occurrence of growth restriction,they were divided into the late-onset intrauterine growth restriction group and non-late-onset intrauterine growth restriction group.PI and β-HCG were measured during the second trimester.Logistic regression was used to analyze the risk factors of intrauterine growth restriction in late-onset fetuses.We also analyzed the value of uterine artery ultrasound PI combined with β-HCG in pre-dicting late-onset fetal intrauterine growth restriction in the second trimester.[Results]There were 31 cases of late-onset intrauterine growth restriction(17.32％)in pregnant women,which were classified as late-onset intrauterine growth re-striction group and 148 cases of non-late-onset intrauterine growth restriction group.There was no statistical significance in age,gestational time,family history of hypertension during pregnancy,systolic blood pressure,TC and albumin be-tween late and non-late intrauterine growth restriction group(P＞0.05).The levels of PI,β-HCG and gestational age in the late intrauterine growth restriction group were higher than those in the non-late intrauterine growth restriction group(P＜0.05).The occurrence of late-onset fetal intrauterine growth restriction was taken as the dependent variable,and PI and β-HCG were taken as independent variables for Logistic multivariate regression analysis(assignment:PI and β-HCG levels were continuous variables),the results showed that PI and β-HCG were risk factors for late-onset intrauterine growth restriction(P＜0.05).ROC curve results showed that the AUC value of PI combined with β-HCG in predicting late-onset intrauterine growth restriction was 0.937,which was higher than that predicted alone(P＜0.05).[Conclu-sion]Both PI and β-HCG are closely related to intrauterine growth restriction of late-onset fetuses,and they can be used to predict intrauterine growth restriction of late-onset fetuses,while the prediction efficiency of PI and β-HCG combined val-ue is higher than either PI or β-HCG alone.
万方数据
维普
