Relationship of Serum Levels of CRP,Hey,and MMP-9 with Concurrent Pneumonia in Elderly Patients with Multiple Cerebral Infarctions
[Objective]To explore the relationship of serum levels of C-reactive protein(CRP),homocysteine(Hey),and matrix metalloproteinase-9(MMP-9)with the occurrence of concurrent pneumonia in elderly patients with multiple cerebral infarctions.[Methods]The clinical data of 80 elderly patients with multiple cerebral infarctions were retrospectively analyzed.The patients were divided into two groups based on whether they had hospital-acquired pneumonia:the concurrent pneumonia group(n=18)and the non-concurrent pneumonia group(n=62).General data and serum levels of CRP,Hey,and MMP-9 were compared between the two groups.The value of CRP,Hey,and MMP-9 levels in predicting concurrent pneumonia was analyzed using receiver operating characteristic(ROC)curves.Multivariate Logistic regression analysis was applied to identify risk factors for concurrent pneumonia.[Re-sults]The proportion of patients aged ≥70 years and those with a history of pulmonary disease was significantly higher in the concurrent pneumonia group than in the non-concurrent pneumonia group(P＜0.05).The levels of CRP,Hcy,and MMP-9 were significantly higher in the concurrent pneumonia group compared to the non-concurrent pneumonia group(P＜0.05).ROC and Logistic analysis showed that the area under the curve(AUC)values of CRP,Hcy,and MMP-9 in predicting concurrent pneumonia were 0.834,0.850,and 0.752,respectively(P＜0.05).Age ≥70 years,a history of pulmonary disease,CRP ≥21.725 mg/L,Hcy ≥21.420 μmol/L,and MMP-9≥385.255 ng/mL were identified as risk factors for concurrent pneumonia(P＜0.05).[Conclusion]Monitoring ser-um levels of CRP,Hcy,and MMP-9 has predictive value for concurrent pneumonia in elderly patients with multiple cerebral infarctions.
万方数据
维普
