The Value of Combined Detection of Serum SAA,IL-12,and IL-6 in Assessing the Severity of Hand,Foot,and Mouth Disease in Children
[Objective]To explore the value of combined detection of serum amyloid A(SAA),interleukin-12(IL-12),and interleukin-6(IL-6)levels in assessing the severity of hand,foot,and mouth disease(HFMD)in children.[Methods]A total of 100 HFMD children were selected as the observation group,and 100 healthy chil-dren undergoing physical examination in the same period served as the control group.The children in the observa-tion group were divided into mild(n=46),severe(n=34),and critical(n=20)groups based on the severity of their conditions.Serum levels of SAA,IL-12,and IL-6 in children with HFMD and healthy children were com-pared.The diagnostic value of these serum levels for HFMD was analyzed using the receiver operating characteris-tic(ROC)curves.The data of children with different severity levels were compared,and the correlation between serum levels of SAA,IL-12,and IL-6 and disease severity was analyzed.[Results]The levels of serum SAA,IL-12,and IL-6 in the observation group were significantly higher than those in the control group(P＜0.05).ROC analysis showed that the areas under the curve(AUC)for serum SAA,IL-12,and IL-6 levels were 0.873,0.843,and 0.840,respectively,with sensitivities of 0.870,0.820,and 0.830,respectively(all P＜0.05).The lev-els of serum SAA,IL-12,and IL-6 in the critical group were significantly higher than those in the mild and severe groups,and their levels in the severe group were significantly higher than those in the mild group(P＜0.05).Correlation analysis showed that the levels of serum SAA,IL-12,and IL-6 were positively correlated with the se-verity of the disease(all P＜0.05).[Conclusion]The levels of serum SAA,IL-12,and IL-6 can predict the severi-ty of HFMD in children.The higher these levels detected,the more severe condition for the child.
Hand,Foot and Mouth DiseaseSerum Amyloid A ProteinInterleukin-12Interleukin-6Child
万方数据
维普
