The Value of Serum TIMP-1,YKL-40,CRP,and ANCA in the Diagnosis and Prognostic As-sessment of Bronchitis in School-aged Children
[Objective]This study investigated the significance of serum tissue inhibitor of metalloprotein-ases-1(TIMP-1),chitinase-3-like protein 1(YKL-40),C-reactive protein(CRP),and anti-neutrophil cyto-plasmic antibodies(ANCA)in the diagnosis and prognostic evaluation of bronchitis in school-aged children.[Methods]One hundred children with bronchitis were selected as the observation group,and one hundred healthy school-aged children undergoing physical examination were selected as the control group.After 1-2 weeks of standard treatment,the observation group was divided into a good prognosis group and a poor prog-nosis group based on treatment outcomes.Levels of TIMP-1,YKL-40,CRP,and ANCA were compared be-tween the observation and the control groups.The diagnostic value of these biomarkers for school-aged bron-chitis was analyzed using receiver operating characteristic(ROC)curves.Additionally,levels of these biomar-kers before and after treatment,as well as between the good and the poor prognosis groups,were compared,and correlations with prognosis were analyzed.[Results]Serum levels of TIMP-1,YKL-40,CRP,and ANCA were significantly higher in the observation group compared to the control group(P＜0.05).ROC analysis confirmed that TIMP-1 228.510 pg/mL,YKL-40 26.755 ng/L,CRP ≥12.130 mg/L,and ANCA 167.850 AU/mL could be used to diagnose bronchitis in school-aged children,with area under the curve values of 0.895,0.892,0.874,and 0.866 respectively(all P＜0.05).After treatment,levels of TIMP-1,YKL-40,CRP,and ANCA in the observation group significantly decreased(P＜0.05).The good prognosis group had lower levels of these markers compared to the poor prognosis group(P＜0.05),and there was a positive cor-relation between these biomarkers and prognosis in children with bronchitis.[Conclusion]Serum levels of TIMP-1,YKL-40,CRP,and ANCA are elevated in children with bronchitis compared to healthy children;The levels of TIMP-1,YKL-40,CRP,and ANCA in bronchitis children decrease after treatment;And they are correlated positively with the prognosis.Clinically,levels of serum TIMP-1,YKL-40,CRP,and ANCA can assist in the diagnosis of bronchitis in school-aged children and in the assessment of prognosis.
Bronchitis/DITissue Inhibitor of Metalloproteinase-1/BLAggrecans/BLC-Reac-tive Protein/BL
万方数据
维普
