Clinical Efficacy of Bifidobacterium Quadripartitum Active Tablets Combined with Antibiotics in Severe Pneumonia Children and their Impact on Gut Microbiota and Inflammatory Cytokine Levels
[Objective]To investigate the clinical efficacy of Bifidobacterium quadruple active tablets com-bined with antibiotics in severe pneumonia(SP)children on gut microbiota,pulmonary ultrasound score(LUS)and inflammatory cytokine levels.[Methods]A total of 102 children with SP admitted to our hospital from Jan-uary 2021 to August 2023 were selected and randomly divided into the control group(conventional symptomat-ic treatment and antibiotic treatment)and the observation group(combined with Bifidobacterium quadruple vi-able tablets on the basis of the control group)using a random number table method,with 51 cases in each group.Two groups were compared in terms of clinical efficacy,pre-and post-treatment lung function indicators[forced expiratory volume in one second(FEV1),vital capacity(VC),LUS],gut microbiota[Escherichia co-li,Bifidobacterium,Enterococcus,Lactobacillus],inflammatory factors[interleukin(IL-10),C-reactive pro-tein(CRP),soluble intercellular adhesion molecule-1(sICAM-1),tumor necrosis factor alpha(TNF-α)]lev-els.[Results]The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After treatment,FEV1,and VC in both groups were higher than before treatment,LUS was lower than before treatment,the difference was statistical significance in two groups(P＜0.05);The levels of Bifidobacterium and Lactobacillus in both groups were higher than be-fore treatment,while the levels of Enterococcus and Escherichia coli were lower than before treatment.The difference between the observation group and the control group was statistically significant(P＜0.05);The levels of IL-10 in both groups were higher than before treatment,while the levels of CRP,sICAM-1,and TNF-α were lower than before treatment.The difference between the observation group and the control group was statistically significant(P＜0.05).[Conclusion]The combination of Bifidobacterium quadruple active tablets and antibiotics has good clinical efficacy in treating SP children,inhibiting inflammatory reactions,and improving lung function in children.
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