Efficacy of Shuxuetong Injection Combined with Alteplase Thrombolysis in Treating Patients with Acute Cerebral Infarction and its Effects on IL-6,TNF-α,and MMP-9 Levels
[Objective]This study aims to explore the efficacy of Shuxuetong injection combined with alteplase thrombolysis in treating patients with acute cerebral infarction and its effects on interleukin-6(IL-6),tumor necrosis fac-tor-alpha(TNF-α),and matrix metalloproteinase-9(MMP-9)levels.[Methods]One hundred patients with acute cere-bral infarction were randomly divided into two groups,with fifty patients in each.The control group received alteplase thrombolysis alone,while the observation group received alteplase thrombolysis treatment combined with Shuxuetong in-jection.The efficacy,neurological function,daily living ability,hemorheological parameters before and after treatment,changes in IL-6,TNF-α,MMP-9,and C-reactive protein(CRP)levels,and the incidence of adverse reactions in both groups were compared.[Results]The total effective rate in the observation group was 92.00％(46/50),which was higher than 82.00％(41/50)in the control group(P＜0.05).After treatment the hemorheological parameters in both groups were lower than those before treatment;And those parameters in the observation group were lower than those in the con-trol group(P＜0.05).Levels of IL-6,TNF-α,MMP-9,and CRP decreased after treatment in both groups,with even lower levels in the observation group compared to the control group(P＜0.05).The National Institute of Health Stroke Scale(NIHSS)scores decreased,and Barthel Index scores increased post-treatment,with better scores in the observation group(P＜0.05).No adverse reactions such as drug allergies,purpura,or bleeding occurred during the treatment in both groups.[Conclusion]Shuxuetong injection combined with thrombolytic therapy can effectively improve hemorheolo-gy,inhibit inflammation,and enhance vascular endothelial function in patients with acute cerebral infarction.Its efficacy is confirmed,and it is worth promoting in clinical applications.
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