Effect of Sevelamer Combined with Hemoperfusion Therapy on Itching Severity and Calcium-phos-phorus Metabolism Indicators in Patients with Uremic Skin Itching
[Objective]To explore the effect of sevelamer combined with hemoperfusion therapy on itching severity and calcium-phosphorus metabolism in patients with uremic skin itching.[Methods]A total of 76 patients with uremic skin itch-ing admitted to the hospital from July 2022 to February 2024 were randomly divided into two groups using a random num-ber table.The control group(n=38 cases)received blood perfusion therapy,while the observation group(n=38 cases)received sevelamer in addition to hemoperfusion of the control group.The itch severity score,inflammatory factors,calcium and phosphorus metabolism indicator,and quality of life were compared between two groups.[Results]After treatment,the sleep score,symptom and sign score,social psychological score,high-sensitivity C-reactive protein(hs-CRP),procalci-tonin(PCT),interleukin-6(IL-6),blood phosphorus,blood calcium,and total parathyroid hormone(iPTH)levels in the observation group were all lower than those in the control group(P＜0.05).The World Health Organization Quality of Life Inventory(WHOQOL-BREF)scores were higher than those in the control group,with significantly statistical differ-ences(P＜0.05).[Conclusion]The application of sevelamer combined with blood perfusion therapy has significant thera-peutic effects,which can alleviate itching symptoms,reduce inflammatory reactions,improve calcium and phosphorus me-tabolism indicators,and enhance quality of life.
万方数据
维普
