Comparison of Anesthetic Effects of Dexmedetomidine and Pethidine in Patients Undergoing Ra-diofrequency Ablation for Liver Cancer
[Objective]To compare the anesthetic effects of dexmedetomidine(Dex)and pethidine on patients undergoing radiofrequency ablation for liver cancer and their impact on regional cerebral oxygen saturation(rSO2).[Methods]A total of 98 patients scheduled for radiofrequency ablation for liver cancer were divided into two groups based on the anesthetic methods:the observation group(Dex,n=50)and the control group(pethidine,n=48).The Ramsay sedation score,heart rate(HR),mean arterial pressure(MAP),rSO2 levels,and incidence of adverse reactions were compared between the two groups at baseline(T0),10 minutes before the start of the procedure(T1),at the end of the procedure(T2),and 24 hours postoperatively(T3).[Results]At T1 and T2,the Ramsay se-dation scores of both groups were higher than that at T0(P＜0.05),and the observation group had higher Ramsay sedation scores than the control group at T1 and T2(P＜0.05).At T1,both groups had lower HR and MAP com-pared to T0,and at T2,both groups had higher rSO2 levels compared to T0(P＜0.05).The control group had low-er HR and MAP at T2 compared to T0,and higher rSO2 at T1 compared to T0(P＜0.05).At T2,the HR and MAP of the observation group were higher than those of the control group(P＜0.05),while rSO2 was lower(P＜0.05).The overall incidence of adverse reactions in the observation group was lower than that in the control group(P＜0.05).[Conclusion]Compared to pethidine,Dex provides better anesthetic effects for patients undergoing radiofre-quency ablation for liver cancer,has a smaller impact on rSO2,and reduces the incidence of adverse reactions.
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