Clinical Effect of Statins on Patients with Coronary Heart Disease Complicated with Carotid Athero-sclerotic Plaque
[Objective]To investigate the effect of rosuvastatin on low density lipoprotein cholesterol(LDL-C)compli-ance rate,symptom remission and carotid plaque in patients with coronary heart disease and carotid plaque.[Methods]A to-tal of 90 patients with coronary heart disease combined with carotid plaque admitted to our hospital from April 2019 to Oc-tober 2020 were selected and divided into the observation group and the control group according to random number method,with 45 cases in each group.The observation group received rosuvastatin lipid-lowering treatment,the control group received simvastatin treatment.LDL-C level and compliance rate,occurrence of adverse reactions and changes of carotid plaque[in-cluding carotid intima-media thickness(IMT),carotid plaque area,thickness and number]were compared between the two groups after treatment.[Results]After treatment,serum LDL-C levels in 2 groups were lower than before treatment,and the observation group was lower than the control group,the difference was statistically significant(P＜0.05).The LDL-C compliance rate in the observation group was significantly higher than that in the control group,with statistical significance(P＜0.05).After treatment,IMT and plaque thickness in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05).There was no significant difference in other carotid plaque indexes between the two groups(P＞0.05).After treatment,the frequency of angina pectoris attacks in 2 groups was lower than before treatment,the duration of angina pectoris attacks was shorter than before treatment,and the obser-vation group was lower than the control group,the difference was statistically significant(P＜0.05).There was no signif-icant difference in the incidence of adverse reactions between the two groups(P＞0.05).[Conclusion]Rosuvastatin has better lipid lowering effect,and is beneficial to improve the symptoms of patients with coronary heart disease and delay the progression of carotid plaque.
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