Expression and Clinical Significance of Galectin-3 and Apelin-12 in Serum of Patients with Hyper-tensive Heart Disease
[Objective]To investigate the serum levels of galectin-3 and Apelin-12 in patients with hypertensive heart disease(HHD)and its clinical significance.[Methods]From October 2019 to October 2021,160 patients with simple hy-pertension were selected as the hypertension group,and 137 patients with HHD were selected as HHD group.The left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),interventricular septal thickness(IVST),left ventricular posterior wall thickness(LVPWT),left atrial diameter(LAD),left ventricular ejec-tion fraction(LVEF),mitral valvular early diastolic peak velocity(E peak)and mitral valvular end diastolic peak velocity(A peak)were measured,and the E/A was calculated.The enzyme linked immunosorbent assay(ELISA)was used to detect serum levels of galectin-3 and Apelin-12,Pearson test was used to analyze the correlation between serum galectin-3 and Apelin-12 levels and cardiac color Doppler ultrasound parameters in patients with HHD;and receiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of serum galectin-3 and Apelin-12 levels in HHD;Multivariate logistic regression model was used to analyze the risk factors of HHD in patients with hypertension.[Re-sults]The systolic blood pressure(SBP),diastolic blood pressure(DBP),LVESD,LVEDD,IVST,LVPWT,LAD and serum galectin-3 level in HHD group were significantly higher than those in hypertension group(P＜0.05),and the course of hypertension in HHD group was significantly longer than that in hypertension group(P＜0.05).While LVEF,E/A and serum Apelin-12 level in HHD group were significantly lower than those in hypertension group(P＜0.05).Pearson analysis showed that serum galectin-3 level was positively correlated with LVESD,LVEDD and LAD(P＜0.05),and negatively correlated with LVEF and E/A(P＜0.05);Apelin-12 level was negatively correlated with LVESD,LVEDD and LAD(P＜0.05),and positively correlated with LVEF and E/A(P＜0.05).The cutoff value of galectin-3 was 7.55 ng/mL,and the sensitivity and specificity were 67.20％and 82.50％,respectively,the cutoff value of Apelin-12 was 305.34 ng/L,the sensitivity and specificity were 73.70％and 71.90％,respectively,the sensitivity and specificity of galectin-3 and Apelin-12 combined diagnosis were 76.60％and 80.60％respectively.The course of hyperten-sion and serum levels of galectin-3 and Apelin-12 were independent risk factors for HHD in patients with hypertension(P＜0.05).[Conclusion]Galectin-3 is highly expressed in HHD patients,and the expression of Apelin-12 is lowly ex-pressed.They are closely related to the structure and function of left ventricle.
万方数据
维普
