Clinical Efficacy of Sulodexide Combined with Epalrestat in the Treatment of Type 2 Diabetes Mellitus Complicated with Diabetic Peripheral Neuropathy
[Objective]To investigate the clinical efficacy of Sulodexide combined with epalrestat in the treatment of type 2 diabetesmellitus(T2DM)patients with diabetic peripheral neuropathy(DPN).[Methods]A total of 95 T2DM patients with DPN treated in our hospital from February 2020 to March 2023 were select-ed and divided into control group(receiving epalrestat treatment,n=46)and observation group(receiving Su-lodexide treatment on the basis of control group treatment,n=49)according to different treatment methods.The clinical efficacy,clinical score,nerve conduction velocity,glycated hemoglobin(HbA1c),fasting blood glucose(FPG),serological indexes and incidence of adverse reactions were compared between the two groups.[Results]The total effective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,the pain,paresthesia,burning sensation,numbness scores and serum malondialde-hyde(MDA)and endothelin-1(ET-1)levels in both groups were lower than before treatment(P＜0.05),and the pain,paresthesia,burning sensation,numbness scores and serum MDA and ET-1 levels in the obser-vation group were lower than those in the control group(P＜0.05).After treatment,the sensory conduction velocity(SNCV),motor conduction velocity(MNCV)and serum nitric oxide(NO)levels of the median nerve and common peroneal nerve in both groups were higher than before treatment(P＜0.05),and the levels of SNCV,MNCV and NO in the median nerve and common peroneal nerve in the observation group were higher than those in the control group(P＜0.05).After treatment,the HbA1c and FPG of both groups were lower than before treatment(P＜0.05),and the HbA1c and FPG of observation group were lower than those of control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions be-tween the two groups(P＞0.05).[Conclusion]Sulodexide combined with epalrestat is effective in the treat-ment of T2DM patients with DPN,and can improve blood glucose control,clinical symptoms,oxidative stress index,vascular endothelial function index,nerve conduction velocity,and is safe and reliable.
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