Effect of Probiotics Combined with Edaravone Injection on Acute Severe Pancreatitis and Changes in Intestinal Flora and Mucosal Barrier Function
Objective To investigate the clinical efficacy of compound lactobacillus acidophilus tablets combined with edaravone in patients with severe acute pancreatitis.Methods A total of 172 patients with severe acute pancreatitis were selected from the First Affiliated Hospital of Henan University of Science and Technology,and they were divided into group A,group B,group C and group D by using random number table,with 43 cases in each group.All four groups were given routine comprehensive treatment,and group B was given edaravone treatment,and group C was given compound lactobacillus acidophilus tablets treatment,and group D was given compound lactobacillus acidophilus tablets combined with edaravone treatment.The intestinal flora,intestinal mucosal barrier function,acute physiology and chronic health score Ⅱ(APACHE Ⅱ)before and after treatment and the length of hospital stay,complications and mortality were compared.Results The abundance of bifidobacterium and lactobacillus in the four groups increased successively before treatment,after 7 days and 14 days of treatment(P＜0.05),and those in the group C and group D after 7 days and 1 4 days of treatment were higher than those in the group A and group B(P＜0.05),and those in group D after 7 days and 14 days of treatment were higher than group C(P＜0.05).The abundance of Enterobacteriaceae,Staphylococcus and Enterococcus in the four groups decreased successively before treatment,after 7 days and 14 days of treatment(P＜0.05),and those in the group C and group D after 7 days and 14 days of treatment were lower than those in the group A and group B(P＜0.05),and those in group D after 7 days and 14 days of treatment were lower than group C(P＜0.05).The levels of D-lactic acid,endotoxin and diamine oxidase(DAO)in the four groups decreased successively before treatment,after 7 days and 14 days of treatment(P＜0.05),and those in the group B,group C and group D after 7 days and 14 days of treatment were lower than those in the group A(P＜0.05),which group B and group D after 7 days and 14 days of treatment were lower than group C(P＜0.05),and those in group D after 7 days and 14 days of treatment were lower than group B(P＜0.05).The hospitalization time of group D was shorter than that of group A,B and C(P＜0.05),and the incidence rate of complications and mortality in group D were lower than those in group A(P＜0.05).The APACHE Ⅱ scores in the four groups decreased successively before treatment,after 7 days and 14 days of treatment(P＜0.05),and those in the group B,group C and group D after 7 days and 14 days of treatment were lower than those in the group A(P＜0.05),which in group D after 7 days and 14 days of treatment were lower than group B and group C(P＜0.05).Conclusion On the basis of routine comprehensive treatment,compound lactobacillus acidophilus tablets can regulate the intestinal flora and improve the intestinal mucosal barrier function of patients with severe acute pancreatitis,and edaravone can improve the intestinal mucosal barrier function,both of which can alleviate the disease,and the combination of the two can enhance the improvement of the intestinal mucosal barrier function and the control of the disease,and it can also significantly shorten the hospital stay,reduce complications and improve the prognosis.
万方数据
维普
