Relationship Between Intestinal Flora and Immune Function in Diabetic Nephropathy Patients
Objective To investigate the relationship between intestinal flora and immune function in diabetic nephropathy patients.Methods A total of 88 patients with type 2 diabetes admitted to the First Affiliated Hospital of Henan University of Science and Technology from June to December 2021 were selected.According to the occurrence of chronic kidney disease,they were divided into simple diabetes group(52 cases)and diabetic nephropathy group(36 cases),and 40 volunteers who underwent physical examination during the same period were selected as the control group.Stool samples were collected in the morning of admission for intestinal bacteria detection to determine the distribution of intestinal flora of patients.Serum samples were collected for the detection of immune function indexes,and the patients'immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM)and CD3+,CD4+,CD4+/CD8+levels were determined.Pearson correlation was used to analyze the relationship between intestinal flora and immune function in diabetic nephropathy patients.Results There was no statistical difference in the number of Lactobacillus and Yeast among the three groups(P＞0.05).The number of Escherichia coli in diabetic nephropathy group was higher than that in simple diabetes group and healthy control group,and the number of Bifidobacterium and Eubacillus number were lower than that in simple diabetes group and healthy control group(P＜0.05).The levels of IgG,IgA,IgM,CD3+,CD4+,CD4+/CD8+were statistical different among the three groups(P＜0.05).The levels of IgG,CD3+,CD4+,CD4+/CD8+in diabetic nephropathy group were higher than those in simple diabetic group and healthy control group,and the IgA and IgM were lower than those in simple diabetes group and healthy control group(P＜0.05).Pearson correlation analysis showed that the number of Escherichia coli was positively correlated with IgG,CD3+,CD4+,CD4+/CD8+,and negatively correlated with IgA and IgM(P＜0.05).The number of Bifidobacterium and Eubacillus were positively correlated with IgA and IgM,and negatively correlated with IgG,CD3+,CD4+,CD4+/CD8+(P＜0.05).Conclusion Intestinal flora distribution of diabetic nephropathy patients is closely related to the immune function of patients.Intestinal flora distribution disorder and immune function decline may be involved in the progression of diabetic nephropathy,which can provide certain guidance for the prevention and treatment of diabetic nephropathy.
diabetic nephropathyintestinal florahumoral immunity indexcell immune indeximmune function
万方数据
维普
