Clinical Value of Remnant Cholesterol Combined with Neutrophil-to-Lymphocyte Ratio in Predicting Type 2 Diabetic Nephropathy
Objective To research the clinical efficacy of remnant cholesterol(RC)combined with neutrophil-to-lymphocyte ratio(NLR)in predicting type 2 diabetic nephropathy(DN).Methods A total of 755 patients with type 2 diabetes mellitus(T2DM)admitted to the First Affiliated Hospital of Zhengzhou University from January 2020 to June 2022 were selected.General clinical data and laboratory indicators were collected and Spearman rank correlation was used to analyze the correlation between RC,NLR and urinary albumin creatinine ratio(UACR).Least absolute shrinkage and selection operator(LASSO)regression was used for data screening and dimensionality reduction.Multivariate logistic regression was further used to establish independent risk factors for DN.The clinical value of RC,NLR and their combination in predicting type 2 diabetic nephropathy was evaluated by receiver operating characteristic(ROC)curve.Results Spearman rank correlation showed that RC and NLR were significantly positively correlated with UACR(r=0.362,0.301,P＜0.05).LASSO-logistic regression results showed that body mass index(BMI),diabetic neuropathy,diabetic retinopathy(DR),systolic blood pressure(SBP),Urea,RC and NLR were independent risk factors for DN.ROC curve showed that the area under the curve(AUC)of RC,NLR and their combined prediction of type 2 diabetic nephropathy were 0.706,0.669 and 0.752,the sensitivity was 0.693,0.649 and 0.712,and the specificity was 0.646,0.667 and 0.679,respectively.The area under the curve predicted by the combination of RC and NLR was higher than that of RC and NLR(Z=2.594,5.115,P＜0.05).Conclusion Both RC and NLR can be used to predict the risk of type 2 diabetic nephropathy,and their combined prediction is more effective.
万方数据
维普
