Clinical Analysis of 35 Children with T Lymphoblastic Lymphoma
Objective To investigate the clinical features and prognosis of children with T-cell lymphoblastic lymphoma(T-LBL).Methods Retrospective analysis was performed for the medical data of 35 children with T-LBL admitted to the First Affiliated Hospital of Zhengzhou University from August 2014 to February 2022,which was grouped according to gender,age,systemic symptoms included fever,night sweats,and weight loss(B symptoms),pleural effusion,lactate dehydrogenase(LDH),clinical stage and recurrence.Overall survival(OS)and event free survival(EFS)rates were calculated by the Kaplan-Meier method.Survival differences between the groups was performed with log-rank test.Results Among the 35 patients included in the current study,24 patients(68.6％)were males and 11 patients(31.4％)were females.The median age of onset was 9(7,11)years,7 patients(20.0％)exhibited bone marrow infiltration and 2 patient(5.7％)showed central nervous system involvement.There were 1 patient with stage Ⅱ T-LBL(2.9％),25 patients with stage Ⅲ T-LBL(71.4％),and 9 patients with stage Ⅳ T-LBL(25.7％).Positive rate of terminal deoxynucleotidyl transferase(TdT),CD99,CD3 and CD7 were 91.4％,100.0％,94.2％and 100.0％,respectively,and different degrees of CD20,CD34,CD10,CD21 and CD30 expression were demonstrated.The 3-year OS rate and EFS rate were 85.6％and 74.4％,respectively.Univariate analysis showed that gender,LDH level and recurrence were the influencing factors of 3-year OS rate(P＜0.05).For 7 children with recurrence,the median time of recurrence was 10.9(5.0,28.0)months and the 3-year OS rate was 38.1％.Conclusion T-LBL is a malignant tumor with high aggressiveness and poor prognosis.Female patients,high LDH and recurrence may indicate poor prognosis in children with T-LBL.
万方数据
维普
