Optimal Timing of Laparoscopic Cholecystectomy After Percutaneous Transhepatic Gallbladder Drainage in Patients with Acute Cholecystitis
Objective To investigate the optimal timing of laparoscopic cholecystectomy(LC)after percutaneous transhepatic gallbladder drainage(PTGBD)in patients with acute cholecystitis.Methods The clinical data of 100 patients with acute cholecystitis who underwent LC after PTGBD in the First Affiliated Hospital of Zhengzhou University from October 2019 to October 2022 were analyzed retrospectively.According to the interval between LC and PTGBD,the patients were divided into group A(47 patients undergoing LC at 5-8 weeks after PTGBD)and group B(53 patients undergoing LC at 3-4 weeks after PTGBD).General data,perioperative indicators,inflammatory factors and the incidence of complications were compared between groups.Results There were no statistically significant differences in age,white blood cell count,gamma-glutamyltransferase,American Society of Anesthesiologists classification,Charlson Comorbidity Index score,or gender between the two groups before LC after PTGBD(P＞0.05).Intraoperative blood loss of group A were less than those of group B,and operation time,exhaust time and hospital stay of group A were shorter than those of group B(P＜0.05).The thickness of gallbladder wall was similar in the two groups(P＞0.05).The levels of tumor necrosis factor,interleukin-2 and C-reactive protein in group A were lower than those in group B(P＜0.05).The incidence of complications in group A(4.26％)was lower than that in group B(18.87％)(P＜0.05).There was no difference in the numbers of patients undergoing conversion to open surgery between the two groups(P＞0.05).Conclusion The optimal timing of LC after PTGBD for patients with acute cholecystitis is 5-8 weeks after PTGBD.
万方数据
维普
