Effects of Intravenous Anesthesia and Intravenous Anesthesia on Myocardial Protection and Immunity in Patients with Lung Cancer After Chemotherapy
Objective To investigate the effects of intravenous anesthesia and intravenous anesthesia on myocardial protection and immunity in patients with lung cancer after chemotherapy.Methods A total of 112 patients with lung cancer who received radical resection after chemotherapy in Henan Provincial Chest Hospital from January 2021 to January 2023 were selected as research objects,and divided into study group and reference group according to random number table method,with 56 cases in each group.The control group was given intravenous anesthesia while the study group was given intravenous anesthesia.Clinical indexes[extubation time,postoperative waking time,operation time,anesthesia onset time,orientation recovery time,instruction time,intraoperative blood loss,postoperative visual analog score(VAS)]were compared between the two groups.Preoperative(T0),intubation side double-lung ventilation for 15 minutes(T1),single lung ventilation for 15 minutes(T2),single lung ventilation for 30 minutes(T3),single lung ventilation for 60 minutes(T4)were used as time points to compare the hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)]of the two groups.Myocardial troponin Ⅰ(cTnⅠ)levels were compared between the two groups at the time points before anesthesia induction(t0),immediately after surgery(t1),6 hours after surgery(t2)and 12 hours after surgery(t3).The levels of immune function indexes(CD3+,CD4+,CD4+/CD8+)and the incidence of complications between the two groups were compared before surgery,1 and 7 days after surgery.Results The effect of anesthesia,extubation,recovery of orientation,following instructions and postoperative wakefulness time of the study group were all shorter than those of the reference group,and the VAS score of the study group was lower than that of the reference group(P＜0.05).MAP and HR levels of the study group were lower than those of the reference group during T1 to T4,and their fluctuation ranges were lower than those of the reference group(P＜0.05).The level of cTnⅠ in t2 and t3 time points was lower than that in the control group(P＜0.05).The levels of CD3+,CD4+,CD4+/CD8+in the study group were higher than those in the control group on 1 and 7 days after surgery(P＜0.05).The total incidence of postoperative complications in the study group(8.93％)was lower than that in the control group(23.21％)(P＜0.05).Conclusion In radical operation of lung cancer,both intravenous anesthesia and intravenous anesthesia have the effects of anesthesia,analgesia,stable hemodynamic level,reducing the incidence of postoperative complications,and improving immune function,but the quality of intravenous anesthesia is higher.
intravascular anesthesiaall intravenous anesthesialung cancerimmune function
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