Predictive Value of Serum VASH-1 and VEGF for the Short-Term Prognosis of Patients with Non-cardioembolic Stroke
Objective To explore the predictive value of serum angiogenesis inhibitory protein-1(VASH-1)and vascular endothelial growth factor(VEGF)for the short-term prognosis of patients with non-cardioembolic stroke.Methods A total of 107 patients with non-cardioembolic stroke admitted to Shangqiu First People's Hospital from December 2020 to December 2022 were selected as the study group,and were divided into poor prognosis group(38 cases)and good prognosis group(69 cases)according to the modified Rankin scale.In addition,93 healthy people in the same period were selected as the control group.The serum levels of VASH-1 and VEGF were detected by enzyme-linked immunosorbent assay within 24 hours after admission.ROC was used to evaluate the value of serum VASH-1 and VEGF in the short-term prognosis of patients with non-cardioembolic stroke.The factors affecting the short-term prognosis of patients with non-cardioembolic stroke were explored by multivariate logistic regression.Results The levels of serum VASH-1 and VEGF in patients with non-cardioembolic stroke in the study group were higher compared with control group(P＜0.05),and the levels of serum VASH-1 and VEGF in patients with non-cardioembolic stroke in the poor prognosis group were higher compared with good prognosis group(P＜0.05).The AUC of serum VASH-1 for evaluating the short-term prognosis of patients with non-cardioembolic stroke was 0.833(95％CI:0.783-0.883).The AUC of serum VEGF in predicting the short-term prognosis of patients with non-cardioembolic stroke was 0.845(95％CI:0.795-0.895).The AUC of the combination of the two markers for evaluating the short-term prognosis of patients with non-cardioembolic stroke was 0.905(95％CI:0.855-0.955).Serum VASH-1(OR=3.662,95％CI:2.124-6.315),VEGF(OR=3.034,95％CI:1.885-4.886)and national institute of health stroke scale(NHISS)(OR=2.683,95％CI:1.771-4.065)and C-reactive protein(OR=3.721,95％CI:2.456-7.36)were all risk factors affecting the short-term prognosis of patients with non-cardioembolic stroke(P＜0.05).Conclusion Serum VASH-1 and VEGF are increased in patients with non-cardioembolic stroke,and the changes in their levels are closely related to the short-term prognosis of the disease,which can be used as biomarkers to predict the short-term prognosis of patients with non-cardioembolic stroke.
万方数据
维普
