Relationship Between DCE-MRI Parameters and Clinicopathological Grading and Prognosis in Elderly Patients with Cervical Cancer
Objective To explore the relationship between dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and clinical staging,pathological grading and prognosis in elderly patients with cervical cancer.Methods A total of 80 elderly patients with cervical cancer from January 2018 to December 2020 were selected as subjects.All patients underwent pelvic DCE-MRI scanning.DCE-MRI parameters were compared among patients with different clinical stages and pathological grades.Spearman correlation analysis was used to analyze the relationship between DCE-MRI parameters and clinical staging and pathological grading,and the prognosis was followed up within 2 years.DCE-MRI parameters were compared between tumor free survival group and progression group and between recurrence group and non-recurrence group.Results Volume fraction(Ve),rate constant(Kep)and volume transfer constant(Ktrans)in patients with clinical stage Ⅲ toⅣ were higher than those inpatients with stage Ⅰ to Ⅱ(P＜0.05).Ve,Kep and Ktrans in highly differentiated patients were lower than those in moderately differentiated patients and poorly differentiated patients(P＜0.05),but there were no statistical differences in Ve,Kep and Ktrans between moderately differentiated patients and poorly differentiated patients(P＞0.05).Spearman correlation analysis showed that Ve,Kep and Ktrans were positively correlated with clinical staging and pathological grading(P＜0.05).Ve,Kep and Ktrans were lower in tumor free survival group than those in progression group(P＜0.05),and Ve,Kep and Ktrans in recurrence group were higher than those in non-recurrence group(P＜0.05).Conclusion DCE-MRI parameters are closely related to pathological staging,pathological grading and prognosis in elderly patients with cervical cancer.
cervical cancerelderlydynamic contrast-enhanced magnetic resonance imagingclinical stagingpathological gradingprognosis
万方数据
维普
