Changes of Serum CCL-2,IL-6,TGF-β1 and SP-A in Children with Mycoplasma Pneumoniae Pneumonia and Their Relationship with Disease Severity
Objective To explore the changes of serum chemokine ligand-2(CCL-2),interleukin-6(IL-6),transforming growth factor-β1(TGF-β1)and pulmonary surfactant-associated protein A(SP-A)in children with mycoplasma pneumoniae pneumonia(MPP)and their relationship with disease severity.Methods A total of 100 children with MPP confirmed in the Sanmenxia Hospital of Yellow River were enrolled as MMP group between June 2019 and June 2022.According to clinical manifestations and imaging findings,they were divided into mild group(62 cases)and severe group(38 cases).A total of 100 healthy children during the same period were enrolled as healthy group.The samples of venous blood were collected to detect and compare levels of serum CCL-2,IL-6,TGF-β1 and SP-A in MPP group and healthy group,and the relationship between the above indexes and MPP severity was analyzed.The diagnostic efficiency of single indexes and combined detection for MMP severity was analyzed by ROC curves.Results The levels of serum CCL-2,IL-6,TGF-β1 and SP-A in MPP group were significantly higher than those in healthy group,and which were higher in severe group than those mild group(P＜0.05).Pearson correlation analysis showed that levels of serum CCL-2,IL-6,TGF-β1 and SP-A were positively correlated with the severity of MPP(P＜0.05).The results of ROC curves analysis showed that area under the curve(AUC)of combined detection in the diagnosis of MPP severity was 0.940,greater than that of single index(P＜0.05).Conclusion The levels of serum CCL-2,IL-6,TGF-β1 and SP-A are increased in MPP children,and which are correlated with the severity of MPP.The combined detection of the four indexes is more conducive to the clinical diagnosis of MPP severity.
mycoplasma pneumoniaechildchemokine ligand-2interleukin 6transforming growth factor-β1pulmonary surfactant-associated protein A
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