Effects of Clindamycin Palmitate Hydrochloride Combined with Cediiodine in Patients with Chronic Periodontitis
Objective To explore the effect of clindamycin palmitate hydrochloride combined with cediiodine in the treatment of chronic periodontitis(CP).Methods The patients with CP in the First Affiliated Hospital of Xinxiang Medical College from May 2021 to March 2022 were retrospectively selected,and 68 patients were divided into two groups with 34 cases each according to different treatment regimens on the principle of 1∶1.The control group was treated with sildeiodide,and the combination group was treated with clindamycin palmitate hydrochloride and sildeiodide.The therapeutic effect,periodontal indexes[plaque index(PLI),gingival index(GI),periodontal pocket probing depth(PD),tooth attachment loss(AL)],pain degree[visual analogue pain scale(VAS)assessment],quality of life[oral health impact profile-CP(OHIP-CP)],serum factor level[triggering receptor expressed on myeloid cell-1(TREM-1),high mobility group protein B-1(HMGB-1),leptin,visfatin],adverse reactions and recurrence rate were compared between the two groups.Results The total effective rate of combined group(97.06％)was higher than that of control group(76.47％)(P＜0.05).After treatment,the scores of PD,AL,PLI,GI,VAS and OHIP-CP in combination group were lower than those in control group(P＜0.05).After treatment,TREM-1,HMGB-1 and visfatin in combination group were lower than those in control group,and leptin was higher than those in control group(P＜0.05).The recurrence rate of combined group(12.12％)was lower than that of control group(34.61％)(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Clindamycin palmitate hydrochloride combined with cediiodine is effective in the treatment of CP,which can improve periodontal condition,relieve pain,improve quality of life,reduce recurrence rate,and is safe and reliable.
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