Hyaluronic acid(HA)is a kind of polymer compound naturally present in human tissues,roughly divided into high molecular weight HA and low molecular weight HA according to different molecular weights,with moisturizing,lubrication,promote cell proliferation,anti-inflammatory and other biological functions.HA with different molecular weights has different functions and sometimes produces different or even opposite effects.Periodontitis is a chronic infectious disease with dental plaque as the starting factor,chronic inflammation will cause alveolar bone resorption,periodontal soft tissue lysis,at which time HA in periodontal tissue can be degraded into different molecular weights fragment.In a series of processes such as the occurrence,development and regeneration of periodontitis,HA of different molecular weights is involved.HA can inhibit inflammation,promote soft tissue healing,induce tissue regeneration,and can open up new ideas for the treatment of periodontal disease.This article reviews the role of HA in periodontitis and the research progress of its clinical application prospects.
万方数据
维普
